It does not have to be long distance.  You could have operating cost issues right across town.  It could even be walking distance.  Or even just an elevator ride away.  This can hit you even if you are just located locally and have no remote locations.
You have grown your company.  You need to add some people.  You are bursting at the seams.  Your lease is not up for a year or two.  You decide to move a department or two to another spot for the short term.
You know the additional costs of the real estate.  You are fine with that.  After all, you would be paying more rent if you could lease more space at your current location.
But you may be missing the highest costs of all.
•    People- it takes your people more time to get things done.  Instead of a walk down the hall, it is a trek across town.  You have to work harder to keep in touch.
•    Communication- it is more work to communicate.  Email has helped, but there is still nothing like talking face to face.  There are still some documents that have to be shuffled back and forth that cannot be handled electronically.
•    Strategy- the left hand may not know what the right hand is doing.  The new location could take on a life of its own.
•    Relationships- you lose some closeness.  Departments that used to work together may start to do battle now.